Figure 5.

EDA inhibited the PM-induced oxidative stress in lung tissues. Mice were intratracheally instilled with PM at 100 μg/day/mouse for 2 consecutive days. EDA (2, 10, or 20 mg/kg) was intraperitoneally injected prior to PM exposure for 1 h. (a) ROS levels in lung tissues were examined by DHE staining. Relative DHE fluorescence is shown in (b). (c) MDA levels were measured in the lung tissues. Values are the mean ± SEM; ^∗P < 0.05 or ^∗∗P < 0.01, compared with the control group; ^#P < 0.05 or ^##P < 0.01, compared with the PM group; n = 3 or 5. EDA: edaravone; PM: particulate matter.