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. 2020 Aug 17;10(50):30186–30202. doi: 10.1039/d0ra05720g

Summary of properties of compounds 32 to 37.

Compound Condition of synthesis Yield (%) Activity Outcome Reference
32–35 32 and 34: 6–8 h reflux of α,β-unsaturated carbonyl compounds with NH2OH·HCl in EtOH 42–62 Anticancer 34f and 34g were the most potent anticancer agents 60
33 and 35: 8 h reflux of 32 and 34 with haloalkylamine in dry acetone in presence of K2CO3
36a–h Reflux of α,β-unsaturated carbonyl compounds with NH2OH·HCl in EtOH 39–51 Anticancer 36g and 36h were the most potent anticancer agents 61
37a–k Stirring of precursors for 5 h at 0–5 °C in dry acetone in presence of K2CO3 48.2–76 Anti-inflammatory 37j was the most potent anti-inflammatory agent 62