Recovery and matrix effect of lapachol in the plasma and brain (n = 4).

Matrix	Spiked	Recovery		Matrix effect
		Mean ± SD (%)	RSD%	Mean ± SD (%)	RSD%
Plasma (ng ml−1)	5	109.74 ± 9.63	8.77	106.80 ± 17.53	16.43
	100	103.50 ± 11.05	10.68	106.45 ± 16.24	15.26
	1000	106.06 ± 9.12	8.60	87.40 ± 2.48	2.83
Plasma (μg ml−1)	1	106.19 ± 9.24	8.70	94.58 ± 13.26	14.02
	20	103,30 ± 11.43	11.07	100.66 ± 2.56	2.54
	100	112.56 ± 1.73	1.54	101.36 ± 6.89	6.06
Brain (ng ml−1)	5	110.74 ± 6.65	6.01	112.52 ± 8.38	7.45
	100	94.70 ± 2.64	2.78	110.36 ± 5.00	4.53
	1000	93.38 ± 4.72	5.06	109.75 ± 7.90	7.19