Pharmacokinetic parameters of lapachol after single i.v. administration of LPC and LPC-LP (6.8 mg kg−1) to rats (n = 6)a.
Parameters | Unit | LPC | LPC-LP |
---|---|---|---|
T 1/2α | Hour | 0.38 ± 0.76 | 2.06 ± 1.87 |
T 1/2β | Hour | 2.42 ± 0.70 | 5.81 ± 1.75** |
AUC (0 − t) | (μg ml−1) h | 52.65 ± 20.10 | 161.71 ± 29.98** |
AUC (0 − ∞) | (μg ml−1) h | 53.51 ± 20.23 | 166.27 ± 31.44** |
CL | mg kg−1 h−1 (μg ml−1)−1 | 0.14 ± 0.06 | 0.04 ± 0.01** |
C max | μg ml−1 | 20.45 ± 4.33 | 47.82 ± 24.48* |
*P < 0.05 and **P < 0.01 vs. the LPC group.