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. 2020 Aug 14;10(50):30025–30034. doi: 10.1039/d0ra05752e

Pharmacokinetic parameters of lapachol after single i.v. administration of LPC and LPC-LP (6.8 mg kg−1) to rats (n = 6)a.

Parameters Unit LPC LPC-LP
T 1/2α Hour 0.38 ± 0.76 2.06 ± 1.87
T 1/2β Hour 2.42 ± 0.70 5.81 ± 1.75**
AUC (0 − t) (μg ml−1) h 52.65 ± 20.10 161.71 ± 29.98**
AUC (0 − ∞) (μg ml−1) h 53.51 ± 20.23 166.27 ± 31.44**
CL mg kg−1 h−1 (μg ml−1)−1 0.14 ± 0.06 0.04 ± 0.01**
C max μg ml−1 20.45 ± 4.33 47.82 ± 24.48*
a

*P < 0.05 and **P < 0.01 vs. the LPC group.