Tanimoto combo scores for compounds 1–4 to different drugs recommended in COVID-19.

Compound	Inhibiting the RNA polymerase		Inhibiting the viral protease		Blocking virus–cell membrane fusion		Prevent cytokine storm
	Remdesivir	Favipiravir	α-ketomide	Lopinavir	Umifenovir	HCQ	Fingolimod
3; chalcone	0.58	0.57	0.64	0.56	0.76	0.66	0.78
4; flavanone	0.71	0.52	0.53	0.58 (retinover = 0.58)	0.75	0.76	0.75
R isomer of 2	0.51	0.77	0.48	0.51	0.86	0.70	0.81
S isomer of 2	0.50	0.78	0.48	0.47	0.86	0.69	0.80
Aglycone of 3	0.53	0.78	0.52	0.57	0.87	0.85
1; ferulic acid-heptyl ester	0.58	0.82	0.52	0.53	0.87	0.73	0.94
Taxifolin	0.54	0.81	0.49	0.45	0.827	0.70	0.73
Remdesiver	2.00	0.51	0.56	0.58	0.75	0.58	0.58
Favipiravir	0.44	2.00
Lopinavir	0.58	0.38	0.63	2.00	0.52	0.52	0.45
α-ketoamide	0.53	0.45	2.00	0.56	0.52	0.51	0.51
N3	0.51	0.30	0.54	0.59	0.45	0.48	0.47
HQC	0.56	0.77	0.54	0.54	0.83	2.00	0.84
CQ	0.52	0.83	0.53	0.59	0.73	1.5	0.71
Umifenovir	0.45	0.66	0.44	049	0.20	0.71	0.54
Fangiloamide	0.56	0.60	0.52	0.45	0.74	0.76	2.00