Synthesis of 2,4-substituted quinazolines via one-pot three-component reaction of 2-aminoaryl ketones, aldehydes, and ammonium acetate^a.

Entry	Reactant 1	Reactant 2	Product	Yieldb (%)
1				88
2				89
3				75
4				74
5				70
6				75
7				85
8				74
9				78
10				75
11				72
12				72
13				75
14				70
15				69
16				84
17				85
18				78
19				68
20				69
21				70
22				68
23				61

^aReaction conditions: reactant 1 (0.1 mmol); reactant 2 (0.2 mmol); NH₄OAc (0.3 mmol); H₂O₂ (0.4 mmol); DMSO (1 mL); 60 °C; under air; 6 h.

^bIsolated yields.