In vitro antitumor activities of the target compounds (IC50, nM).
| Compounds | IC50 (nM) |
|---|---|
| Hep3B | |
| 3a | N.D.a |
| 3b | N.D. |
| 3f | N.D. |
| 3g | N.D. |
| 3h | >10 000 |
| 3i | >10 000 |
| 3j | 4986.0 |
| 3k | >10 000 |
| 3l | N.D. |
| 3m/3m′ | N.D. |
| 3n/3n′ | N.D. |
| 3o/3o′ | N.D. |
| 3p/3p′ | N.D. |
| 4 | 601.7 |
| Infigratinib | 224.2 |
Not determined.