TOPKAT analysis of curcuminoids.

Compound name	NTP carcinogena	Ames mutagena	Rat TD50b	Rat oral LD50c	Rat inhalation LC50d	Fathead minnow LC50d	Daphnia EC50e
Keto-curcumin	NC	NM	57.8227	2.81353	1200.80	0.000386	1.61229
Hexahydroxycurcuminol	NC	NM	1.53493	14.2048	1538.66	0.005549	0.481126
Dihydrocurcumin	NC	NM	63.4126	8.19582	1048.43	0.000318	1.05586
Octahydrocurcumin	NC	NM	1.53493	14.2048	1538.66	0.005549	0.481126
Tetrahydrocurcumin	NC	NM	25.0721	11.8342	1126.18	0.000875	0.600233
Alpha-turmerone	NC	NM	72.5357	1.09783	23297.40	0.000578	8.87751
Beta-turmerone	NC	NM	55.48	1.38263	26 058	0.000136	6.67372
Bisdemethoxycurcumin	NC	NM	168.944	1.00939	657.833	0.000988	3.7944
Hexahydrocurcumin	NC	NM	1.13932	8.65315	1963.47	0.004877	1.09273
Demethoxycurcumin	NC	NM	58.7615	2.39167	1645.26	0.000454	3.67163
Cyclocurcumin	NC	NM	24.1476	1.76033	3601.59	0.001092	1.03814
Curcumin glucuronide	NC	NM	1.42569	8.725	74.3232	0.004108	0.687055
Ar-turmerone	NC	NM	100.468	1.43641	16932.10	0.001595	26.6017
Enol-curcumin	NC	NM	53.0906	3.39621	927.783	0.000536	0.391523

^aNon-Carcinogen (NC), Non-Mutagen (NM).

^bTD50 (mg per kg body weight per day).

^cLD50 (g per kg body weight), mg m⁻³ h⁻¹.

^dLC50 (g L⁻¹).

^eEC50 (mg L⁻¹).