Extension of reaction substrate.
| |||||
|---|---|---|---|---|---|
| Entrya | Nucleophiles | Product | Yieldb (%) | M.P./°C | |
| Found | Report (Lit) | ||||
| 1 |
|
|
98 | 140–142 | 142–143 (ref. 37) |
| 2 |
|
|
88 | 158–160 | 134–135 (ref. 29) |
| 3 |
|
|
91 | 189–191 | 187–189 (ref. 29) |
| 4 |
|
|
98 | 176–178 | 183–191 (ref. 37) |
| 5 |
|
|
88 | 154–155 | 142–145 (ref. 37) |
| 6 |
|
|
90 | 168–169 | 184–186 (ref. 37) |
| 7 |
|
|
93 | 151–153 | 145–147 (ref. 37) |
| 8 |
|
|
93 | 169–172 | 155–158 (ref. 37) |
| 9 |
|
|
95 | 158–160 | — |
| 10 |
|
|
92 | 193–195 | 186–187 (ref. 29) |
| 11 |
|
|
91 | 193–194 | 176–178 (ref. 37) |
| 12 |
|
|
88 | 110–112 | 113–119 (ref. 36) |
| 13 |
|
|
91 | 136–138 | 139–141 (ref. 37) |
| 14 |
|
|
90 | 184–186 | — |
| 15 |
|
|
92 | 74–76 | 77–80 (ref. 31) |
| 16 |
|
|
95 | 189–191 | 192 °C (ref. 36) |
| 17 | Me3SiN3 |
|
90 | White oil | White oil36 |
Reaction conditions: xanthen-9-ol (0.5 mmol), indoles (0.5 mmol), ionic liquid (0.1 eq.), 50 °C, 4 h.
Isolated yields.