Fig. 1. Simulated γ-secretase models bound to C83 and Notch100 within a lipid bilayer. (A) Wild-type γ-secretase–C83 complex. (B) Wild-type γ-secretase–Notch100. The subunits nicastrin (green), PS1 (blue), APH1-A (magenta), PEN2 (yellow), and the substrates C83/Notch100 (orange) are coloured differently. The small spheres represent the head groups of the POPC molecules. The trans-membrane sequences of the two substrates are shown below the structures (acc: accessibility and hyd: hydrophobicity). The arrows show the position of the cleavage sites in C83 and Notch100. The images were generated using ENDScript2.0.
