Fig. 11. Computed stability effects (ΔΔGMUT, kcal mol−1) for 149 pathogenic PS1 mutations of substrate-bound γ-secretase (6IYC and 6IDF). The median is shown as a white dot inside the violin plot. (A and D) Computed ΔΔGMUT for 6IYC and 6IDF using (A) I-Mutant, (B) FoldX, (C) POPMUSIC and (D) mCSM. (E–H) Linear correlation between ΔΔGMUT of the 149 mutations for 6IYC and 6IDF computed using (E) I-Mutant, (F) FoldX, (G) POPMUSIC and (H) mCSM.
