Fig. 3. Main atomic dynamics of γ-secretase–C83 and Notch100 complexes. (A–C) The movement of NCT (green), PS1 (cyan), APH1-A (purple), PEN2 (yellow), and C83 (tint grey) of γ-secretase–C83 for simulation 1 (A), 2, (B), and 3 (C). (D–F) The movement of the NCT, PS1, APH1-A, PEN2, and Notch100 (tint grey) of γ-secretase–Notch100 for simulation 1 (D), 2, (E), and 3 (F). The red arrows represent the direction and amplitude of motion. The TM domains in PS1 are marked 1, 2, 3, 4, 5, 6, 6a, 7, 8 and 9.