Fig. 6. Simulated minimum distances between catalytic Asp257/Asp385 and cleavage sites of C83 and Notch100. Left panels: average distances between the catalytic residues of PS1 and cleavage sites in C83 (Leu720–Val721 giving the Aβ49 pathway and Thr719–Leu720 giving the Aβ48 pathway). Right panel: average distances between the catalytic residues and cleavage sites of Notch100 (Gly1753 and Val1754).
