Statistics of the simulationsa.
| Complexes | MD systems | RMSD (nm) | R g (nm) | SASA (nm2) | RMSF (nm) | Distance (nm) | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Nicastrin | PS1 | APH1-A | PEN2 | C83/Notch100 | Asp–Asp | |||||
| γ-Secretase–C83 | 1 | 0.28 (0.02) | 4.03 (0.02) | 604.6 (6.40) | 0.14 (0.05) | 0.12 (0.04) | 0.13 (0.03) | 0.13 (0.02) | 0.11 (0.03) | 1.15 (0.02) |
| 2 | 0.31 (0.03) | 4.01 (0.02) | 609.8 (5.46) | 0.14 (0.05) | 0.11 (0.04) | 0.12 (0.03) | 0.12 (0.03) | 0.14 (0.04) | 1.15 (0.04) | |
| 3 | 0.30 (0.03) | 3.99 (0.02) | 613.2 (7.24) | 0.15 (0.06) | 0.13 (0.03) | 0.13 (0.04) | 0.18 (0.05) | 0.12 (0.02) | 1.14 (0.03) | |
| γ-Secretase–Notch100 | 1 | 0.30 (0.05) | 3.97 (0.02) | 613.5 (7.48) | 0.17 (0.06) | 0.10 (0.03) | 0.13 (0.04) | 0.16 (0.05) | 0.16 (0.09) | 1.00 (0.02) |
| 2 | 0.28 (0.02) | 3.95 (0.02) | 611.7 (4.29) | 0.13 (0.04) | 0.10 (0.03) | 0.12 (0.03) | 0.13 (0.04) | 0.14 (0.05) | 1.01 (0.02) | |
| 3 | 0.30 (0.03) | 3.94 (0.04) | 621.0 (7.05) | 0.15 (0.05) | 0.15 (0.04) | 0.13 (0.04) | 0.22 (0.05) | 0.21 (0.09) | 1.02 (0.02) | |
a
Values within parenthesis represent the standard deviations.