Fig. 3.

Percent decrease of severe hypoglycemic events between/within groups in the three study periods. In the IG, it was markedly greater than in the CG (p < 0.0001) during the first follow-up period (B) after randomization (A) and only slightly greater (p < 0.042) in the second one (C). For within-group results, the decrease observed in the IG was already impressive (p < 0.0001) in the first follow-up period (B) after randomization (A) and continued (p < 0.0001) during the second one (C) while the decrease observed in the CG, besides being much smaller than in the IG, followed an opposite trend, being much more prominent (p < 0.01) in the first follow-up period (B) after randomization (A) than in the second one (C) [p < 0.031 vs. A and p < 0.05 vs. B). A = T-6/T0 (pre-randomization period); B = T0/T + 6 (first 6-month follow-up period); C = T + 6/T + 12 (second 6-month follow-up period). *p < 0.05; **p < 0.01; ***p < 0.0001