Table 5.

Multivariate analysis of factors significantly associated with severe and symptomatic HYPOs

	(95% CI)	RR
Factors associated with severe hypoglycemia (SeH)
Diameter ≥ 4 cm	2.24–5.37	3.38
Abdominal site	1.55–2.88	2.04
LH at the abdominal site	1.86–2.91	2.38
LHs at multiple sites	2.68–4.79	3.95
Needle reuse	2.22–3.87	3.46
Failure to rotate injection sites	2.89–4.90	3.67
Insulin dose > 40 units/day	1.15–2.19	1.68
Ice-cold insulin	2.75–4.88	3.39
Factors associated with symptomatic hypoglycemia (SyH)
LH at the abdominal site	1.22–2.63	2.17
LHs at multiple sites	1.85–2.78	2.39
Injection into LH nodules	2.59–5.98	4.21
Needle reuse	2.25–6.65	4.74
Failure to rotate injection sites	2.48–4.56	3.49
Insulin dose > 40 units/day	1.93–2–21	1.48
Post-injection drop-leaking	0.98–1.88	1.21
Ice-cold insulin	2.06–3.98	2.58