Lipohypertrophy (LH) is a complication affecting almost 50% of insulin-treated patients and is responsible for poor metabolic control and hazardous, unpredictable hypoglycemic events (HYPOs).

In our study, a single education session on correct injection techniques, which reflects everyday clinical practice worldwide, failed to improve unhealthy habits or decrease the LH rate efficiently.

To our knowledge, our study was the first 18-month educational trial to show that a relentless behavioral rehabilitation strategy can sustainedly and dramatically decrease LH-related prevalence of HYPOs.

If adapted to individual contexts, our experimental model can dramatically reduce the high costs of LH-related HYPOs and improve the quality of life of insulin-treated patients worldwide.