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. 2022 Apr 30;12:7083. doi: 10.1038/s41598-022-11151-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Clinical courses and phylogenetic analyses of four post-liver transplant (LT) patients during serial anti-HCV treatments by interferon-based therapy with DAA and interferon-free DAA therapy. Change of serum HCV RNA levels and HCV clones with resistance-associated substitutions at NS3 D168, NS5A L31, L32, and Y93 in four LT patients (left panels). Phylogenetic analyses of four LT patients at pre-simeprevir, interferon, and ribavirin therapy (SMV/IFN/RBV) (blue dots), post- SMV/IFN/RBV (orange dots), and pre- daclatasvir, and asunaprevir therapy (DCV/ASV) (black dots) (middle panels). Phylogenetic analyses of four LT patients at pre-DCV/ASV (black dots), post-DCV/ASV (red dots), and 18 months (M) post-DCV/ASV (green dots) (right panels).