Scheme 11. Synthesis of 4,5,6,7-tetrahydrobenzo [1,2-d] thiazole derivative compounds 229–240. Reagents and conditions: (a) corresponding carboxylic acids, EDC, HOBt, NMM, DMF, r.t., 18 h; (b) acetyl chloride, MeOH, 0 °C, 1 h, then r.t., 18 h.
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