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| Compounds | IC50 (μM) ± SD | SI | |||
|---|---|---|---|---|---|
| PKO AS-45-1 | HeLa | WL-26VA4 | PKO AS-45-1 | HeLa | |
| 98 | >300 | >300 | >300 | nd | nd |
| 99 | 23.7 ± 1.7 | 8.1 ± 2.7 | 37.8 ± 5.0 | 1.59 | 4.66 |
| 100 | 5.1 ± 1.1 | 4.0 ± 0.8 | 6.4 ± 0.7 | 1.25 | 1.60 |
| 101 | 3.2 ± 1.7 | 9.4 ± 0.7 | 11.3 ± 1.4 | 3.53 | 1.20 |
| 102 | >400 | >400 | >400 | nd | nd |
| 103 | >300 | 191.8 ± 10.1 | 167.0 ± 10.5 | nd | 0.87 |
| 104 | 19.1 ± 4.4 | 8.5 ± 2.4 | 99.1 ± 11.2 | 5.18 | 11.65 |
| 105 | 131.9 ± 16.8 | 8.8 ± 1.9 | 34.1 ± 6.5 | 0.25 | 3.87 |
| Etoposide | 1.4 ± 0.6 | 2.7 ± 0.4 | nd | — | — |
