The obtained values of the FPL calculations.
| No. | Name | F Max a | W b | ΔGEXPc |
|---|---|---|---|---|
| 1 | 11r | 857.5 ± 38.7d | 94.6 ± 5.0d | −9.23 |
| 2 | 13a | 496.0 ± 32.5d | 43.3 ± 3.9d | −7.70 |
| 3 | 13b | 884.2 ± 36.5d | 91.9 ± 3.6d | −8.45 |
| 4 | 11a | 701.3 ± 54.1 | 70.7 ± 5.9 | −9.96 |
| 5 | 11b | 718.7 ± 46.8 | 74.3 ± 4.4 | −10.13 |
| 6 | Carmofur | 421.5 ± 23.9 | 32.6 ± 1.8 | −7.86 |
| 7 | Disulfiram | 371.3 ± 20.3 | 24.5 ± 1.9 | −6.89 |
| 8 | Ebselen | 381.0 ± 34.0 | 23.5 ± 2.5 | −8.45 |
| 9 | PX-12 | 321.3 ± 26.5 | 16.5 ± 1.7 | −6.39 |
| 10 | Shikonin | 327.9 ± 24.4 | 21.2 ± 2.1 | −6.58 |
| 11 | Tideglusib | 351.8 ± 32.4 | 26.3 ± 2.4 | −7.95 |
a
The obtained value of the mean rupture force FMax.
b
The recorded metric of the pulling work W.
c
The experimental binding free energy ΔGEXP was coarsely estimated via the reported IC50 (ref. 11–14) with a supposition that the IC50 value is equal to the inhibition constant ki.
d
The values were reported in the previous work.15 The calculated error was the standard error of the average. The unit is in kcal mol−1.