Optimization of reaction conditions for synthesis of 1-phenyl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethan-1-one^a.

Entry	Solvent	Catalyst (mol%)	Temp. (°C)	Time (min)	Yieldb (%)
1	Water	0.2	80	30	98
2	EtOH	0.2	Reflux	30	80
3	MeOH	0.2	Reflux	30	75
4	CH3CN	0.2	Reflux	90	65
5	DMF	0.2	80	90	70
6	Neat	0.2	80	30	40
7	Water	No catalyst	80	180	30
8	Water	0.1	80	60	80
9	Water	0.3	80	30	97
10	Water	0.2	25	90	45
11	Water	0.2	40	60	55
12	Water	0.2	50	45	75
13	Water	0.2	60	30	92
14	Water	0.2	65	30	97
15	Water	0.2	70	30	97
16	Water	0.2	80	30	98

^aReaction conditions: acetophenone (1.0 mmol), alkyne (1.0 mmol), sodium azide (1.2 mmol), catalyst (0.2 mol%) sodium ascorbate (2.5 mol%) and H₂O (3 ml), 65 °C.

^bIsolated yield.