Fig. 5. The skull defects of the material treatment group and the control group were scanned at 4 and 8 weeks after surgery. New bone tissue was filled with skull defects covered by sPL-NFS. No defect was observed in other material groups at 4 weeks after surgery. A bone defect was observed in the S4 material group and the other one became smaller. At 8 weeks postoperatively, all bone defects were repaired, and the entire skull defect was filled in the S4 bone tissue, to find a site of significant bone defects; the callus was reconstructed and flush with the bone surface of the untreated site.
