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. 2020 Sep 22;10(58):35072–35089. doi: 10.1039/d0ra06811j

Antifeedant effects of DAs on L. decemlineata and S. littoralis and cytotoxicity on Sf9 cells.

Compounds Type L. decemlineata (EC50, μg cm−2) S. littoralis (EC50, μg cm−2) Sf9 cells (LD50, μg mL−1)
14-O-Demethyldelboxine (2) I 1.92 ≈50 6.27
14-Demethyltuguaconitine (3) I 2.36 5.38 >100
Tuguaconitine (4) I 3.31 11.79 1.83
Pubescenine (6) III 12.53 >50 >100
Raveyine (9) III 0.99 >50 >100
Ajadelphinine (19) III 4.43 >50 >100
Ajadine (31) IV 0.84 0.42 >100
14-Deacetylajadine (32) IV nt nt >100
18-Hydroxy-14-O-methylgadesine (49) IV 0.13 >50 >100
18-Demethylpubescenine (51) IV 0.60 >50 29.17
1-O,19-Didehydrotakaosamine (56) IV 1.49 14.29 >100
8-O-Methylconsolarine (57) IV 0.23 >10 >100
14-O-Deacetylpubescenine (58) IV ≈50 17.99 0.38
18-O-Benzoyl-14-O-deacetyl-18-O-demethylpubescenine (59) IV nt nt >100
18-Methoxygadesine (60) IV 6.36 >50 >100
Consolidine (61) IV ≈50 9.86 >100
Olivimine (62) IV 10.92 >50 >100
Olividine (63) IV 3.62 3.33 29.45
Gigactonine (75) IV 13.02 9.31 >100
Delcosine (76) IV 1.11 3.53 32.37
Deltatsine (78) IV 0.54 0.84 >100
Delsoline (79) IV 2.22 >50 >100
Lycoctonine (80) IV >50 >50 >100
Takaosamine (81) IV 0.66 5.29 >100
Delphatine (82) IV 2.97 2.72 >100
Browniine (84) IV nt Nt >100
14-Acetyldelcosine (87) IV >50 1.51 14.88
14-O-Acetyldelectinine (91) IV 0.29 5.63 >100
Dihydroajaconine (96) V 5.0 >50 >100
Isoatisine (99) V 3.4 >50 >100
Ajaconine (100) V 5.1 8.2 >100
Glandulosine (107) VI 4.0 >50 >100
Hetisine (113) VI 1.73 ≈50 >100
Atropine 7.38 >50 >100
Anabasine >50 ≈60 >100
Eserine ≈60 >50 >100