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. Author manuscript; available in PMC: 2023 Apr 19.
Published in final edited form as: Circulation. 2022 Feb 4;145(16):1218–1233. doi: 10.1161/CIRCULATIONAHA.121.056850

Figure 1. Identification of exercise-associated cardiac lncRNAs (lncExACTs).

Figure 1.

A. Volcano plot showing lncRNA RNAseq results in hearts from exercised compared with sedentary mice, n=4 mice/group. B. Venn diagram of differentially regulated cardiac lncRNAs in exercised (Run) mice and animals with transverse aortic constriction (TAC)-induced left ventricular hypertrophy (TAC-LVH) or heart failure (TAC-HF), n=4 mice/group. C. QRT-PCR measurement of cardiac lncExACT1–5 expression in control (Ctrl), exercised (Run), TAC-LVH, or TAC-HF mice. *p<0.05 vs. Ctrl by one-way analysis of variance (ANOVA) with post hoc Tukey, n=4–5 mice/group. D. lncExACT1 expression measured by QRT-PCR is increased in hearts from heart failure (HF) patients compared with controls, n=12/group. p<0.001 by Student’s t test. E. Plasma lncExACT1 determined by ddPCR is increased in patients with HF with reduced ejection fraction (HFrEF, n=18) or HF with preserved ejection fraction (HFpEF, n=16) in comparison to supraventricular tachycardiac (SVT) patients without HF (n=8). p=0.006 and p=0.032 by pairwise Wilcoxon rank sum test with Bonferroni correction. Data shown as mean±SEM.