Fig. 1. AptNCL aptamer design. (A) Chemical representation of the quadruplex structure of cholesterol-conjugated NCL aptamer via poly thymine (T12) and tetraethyleneglycol (TEG) linker (AptNCL). (B) Intraliposomal active loading of CRM-modified β-cyclodextrins complexes into liposomes core via pH gradient method. (C) AptNCL post-insertion on the surface of preformed actively loaded liposomes.
