Proteins involved in autophagy and the DNA damage response pathway. Adapted from Feng, Y., He, D., Yao, Z., et al., 2014, Cell Res., 24, 24–41. M. A. Hayat (ed): Autophagy, vol. 11, DOI: 10.1016/B978-0-12-805420-8.00010-X. (Re-use permission taken from the corresponding author through email).
| Proteins involved in autophagy | Yeast | Mammals | Proteins involved in DNA damage check-point signalling | Mammals | Yeast |
|---|---|---|---|---|---|
| Sensors | |||||
| Atg1/ULK complex | Atg1 | ULK1/2 | 9-1-1 clamp and clamp loader | Rad17 | Rad24 |
| Atg13 | ATG13 | Rad9 | Ddc1 | ||
| Atg17 | FIP200 | Rad1 | Rad17 | ||
| (Functional homolog) | Hus1 | Mec3 | |||
| Atg29 | — | ||||
| Atg31 | |||||
| Atg11 | |||||
| Atg2 | ATG2 | ||||
| Atg9 and its cycling system | Atg9 | ATG9A/B | BRCT-containing | BRCA1 | Rad9 |
| Atg18 | WIPI1/2 | TopBP1 | Dpb11 | ||
| PtdIns3K complexes | Vps34 | PIK3C3/VPS34 | MRX complexes | Mre11 | Mre 11 |
| Vps15 | PIK3R4/VPS15 | Rad50 | Rad50 | ||
| Vps30/Atg6 | BECN1 | Nbs1 | Xrs2 | ||
| Atg14 | ATG14 | ||||
| Transducers | |||||
| Atg8 Ubl conjugation system | Atg8 | LC3A/B/C | PI3-kinases (PIKK) | ATR | Mec1 |
| GABARAP | ATM | Tel1 | |||
| GABARAPL1/2 | |||||
| Atg7 | ATG7 | ||||
| Atg3 | ATG3 | ||||
| Atg4 | ATG4A/B/C/D | ||||
| Atg12 Ubl conjugation system | Atg12 | ATG12 | PIKK binding partner | ATRIP | Ddc2/Lcd1 |
| Atg7 | ATG7 | ||||
| Atg10 | ATG10 | ||||
| Atg16 | ATG16L1 | ||||
| Atg5 | ATG5 | ||||
| Effector kinases | Chk1 | Chk1 | |||
| Chk2 | Rad53 | ||||