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Systemic phenotype in chronic exposure to cigarette smoke. (A) Changes to body weight during the first 3 months (n = 18–20). (B) CS groups showed increases in the plasma cotinine levels (n = 5–7). (C) Plasma CRP concentrations were not significantly changed in all three strains (n = 6). (D) Smoking altered the profile of systemic inflammatory mediators (n = 4–5).
