TABLE 1.
Susceptibilities of 5,558 clinical isolates to ertapenem and three comparator drugs
| Microorganism(s) (no. of isolates) and antimicrobial agentb | MIC (μg/ml)
|
||
|---|---|---|---|
| Range | 50% | 90% | |
| Acinetobacter spp.a (86) | |||
| Ertapenem | 0.06–>16 | 4.0 | 16 |
| Imipenem | ≤0.008–>16 | 0.25 | 2.0 |
| Amox-clav | 0.06–>32 | 16 | >32 |
| Ciprofloxacin | ≤0.008–>16 | 1.0 | >16 |
| Aeromonas spp.c (21) | |||
| Ertapenem | 0.03–1.0 | 0.06 | 0.25 |
| Imipenem | 0.25–4.0 | 0.5 | 2.0 |
| Amox-clav | 16–>32 | 32 | >32 |
| Ciprofloxacin | ≤0.008–1.0 | 0.016 | 0.12 |
| Burkholderia cepacia (13) | |||
| Ertapenem | 4.0–>16 | 8.0 | >16 |
| Imipenem | 8.0–>16 | 16 | >16 |
| Amox-clav | 32–32 | >32 | >32 |
| Ciprofloxacin | 1.0–>16 | 4.0 | >16 |
| Citrobacter spp.d (216) | |||
| Ertapenem | ≤0.008–4.0 | ≤0.008 | 0.25 |
| Imipenem | 0.06–2.0 | 0.5 | 1.0 |
| Amox-clav | 2.0–>32 | 16 | >32 |
| Ciprofloxacin | ≤0.008–>16 | 0.03 | 1.0 |
| Enterobacter spp.e (239) | |||
| Ertapenem | ≤0.008–>16 | 0.03 | 0.5 |
| Imipenem | 0.12–>16 | 1.0 | 2.0 |
| Amox-clav | 1.0–>32 | >32 | >32 |
| Ciprofloxacin | ≤0.008–>16 | 0.03 | 1.0 |
| Escherichia coli (254) | |||
| Ertapenem | ≤0.008–0.5 | ≤0.008 | 0.016 |
| Imipenem | 0.06–2.0 | 0.12 | 0.25 |
| Amox-clav | 1.0–>32 | 8.0 | 32 |
| Ciprofloxacin | ≤0.008–>16 | 0.03 | 0.06 |
| Klebsiella spp.f (359) | |||
| Ertapenem | ≤0.008–>16 | ≤0.008 | 0.03 |
| Imipenem | 0.06–>16 | 0.25 | 0.5 |
| Amox-clav | 1.0–>32 | 4.0 | 16 |
| Ciprofloxacin | ≤0.008–>16 | 0.06 | 1.0 |
| Pasteurella multocida (22) | |||
| Ertapenem | ≤0.008–0.03 | 0.016 | 0.03 |
| Imipenem | 0.03–0.5 | 0.25 | 0.5 |
| Amox-clav | 0.06–0.5 | 0.25 | 0.5 |
| Ciprofloxacin | ≤0.008–0.06 | ≤0.008 | 0.016 |
| Proteeaeg (284) | |||
| Ertapenem | ≤0.008–4.0 | 0.016 | 0.03 |
| Imipenem | 0.016–16 | 4.0 | 4.0 |
| Amox-clav | 0.5–>32 | 16 | >32 |
| Ciprofloxacin | ≤0.008–>16 | 0.06 | >16 |
| Pseudomonas aeruginosa (161) | |||
| Ertapenem | 0.12–>16 | 8.0 | >16 |
| Imipenem | 0.25–>16 | 2.0 | 8.0 |
| Amox-clav | 32–>32 | >32 | >32 |
| Ciprofloxacin | 0.03–>16 | 0.5 | >16 |
| Pseudomonas spp.h (29) | |||
| Ertapenem | ≤0.008–>16 | 8.0 | >16 |
| Imipenem | 0.12–>16 | 1.0 | >16 |
| Amox-clav | 1.0–>32 | >32 | >32 |
| Ciprofloxacin | ≤0.008–>16 | 0.25 | 1.0 |
| Salmonella spp.i (112) | |||
| Ertapenem | ≤0.008–0.06 | ≤0.008 | ≤0.008 |
| Imipenem | 0.12–1.0 | 0.25 | 0.5 |
| Amox-clav | 1.0–>32 | 1.0 | 16 |
| Ciprofloxacin | ≤0.008–0.12 | 0.016 | 0.03 |
| Serratia marcescens (110) | |||
| Ertapenem | ≤0.008–>16 | 0.03 | 0.12 |
| Imipenem | 0.12–>16 | 1.0 | 2.0 |
| Amox-clav | 4.0–>32 | >32 | >32 |
| Ciprofloxacin | ≤0.008–>16 | 0.25 | 4.0 |
| Shigella spp.j (37) | |||
| Ertapenem | ≤0.008 | ≤0.008 | ≤0.008 |
| Imipenem | 0.06–0.5 | 0.25 | 0.25 |
| Amox-clav | 4.0–32 | 16 | 32 |
| Ciprofloxacin | ≤0.008–0.25 | ≤0.008 | 0.06 |
| Stenotrophomonas maltophilia (54) | |||
| Ertapenem | 1.0–>16 | >16 | >16 |
| Imipenem | 8.0–>16 | >16 | >16 |
| Amox-clav | 4.0–>32 | >32 | >32 |
| Ciprofloxacin | 1.0–>16 | 8.0 | >16 |
| Miscellaneous gram-negative bacteriak (22) | |||
| Ertapenem | ≤0.008–>16 | 0.03 | 4.0 |
| Imipenem | 0.06–>16 | 1.0 | 4.0 |
| Amox-clav | 0.12–>32 | 8.0 | 32 |
| Ciprofloxacin | ≤0.008–>16 | 0.5 | 4.0 |
| Haemophilus spp.l (332) | |||
| Ertapenem | ≤0.008–0.5 | 0.03 | 0.06 |
| Imipenem | ≤0.008–2.0 | 0.5 | 1.0 |
| Ampicillin | 0.12–>4.0 | 0.5 | >4.0 |
| Ciprofloxacin | ≤0.008–16 | 0.016 | 0.03 |
| Moraxella catarrhalis (181) | |||
| Ertapenem | ≤0.008–0.25 | ≤0.008 | 0.016 |
| Imipenem | ≤0.008–1.0 | 0.12 | 0.25 |
| Ampicillin | ≤0.03–1.0 | 0.25 | 0.5 |
| Ciprofloxacin | ≤0.008–0.5 | 0.016 | 0.03 |
| Neisseria meningitidis (27) | |||
| Ertapenem | ≤0.008–0.03 | ≤0.008 | 0.016 |
| Imipenem | 0.03–1.0 | 0.25 | 0.5 |
| Ampicillin | 0.12–0.5 | 0.12 | 0.25 |
| Ciprofloxacin | ≤0.008 | ≤0.008 | ≤0.008 |
| Corynebacterium spp.m (29) | |||
| Ertapenem | ≤0.008–>16 | 0.5 | >16 |
| Imipenem | ≤0.008–>16 | 1.0 | >16 |
| Amox-clav | ≤0.03–>32 | 0.5 | >32 |
| Ciprofloxacin | 0.5–>16 | >16 | >16 |
| Enterococcus faecalisn (387) | |||
| Ertapenem | 0.06–>16 | 8.0 | >16 |
| Imipenem | 0.03–>16 | 2.0 | 16 |
| Amox-clav | 0.06–>32 | 0.5 | 1.0 |
| Ciprofloxacin | 0.25–>16 | 1.0 | >16 |
| Enterococcus faeciumo (140) | |||
| Ertapenem | 0.12–>16 | >16 | >16 |
| Imipenem | 0.25–>16 | >16 | >16 |
| Amox-clav | 0.06–>32 | >32 | >32 |
| Ciprofloxacin | 0.25–>16 | >16 | >16 |
| Enterococcus spp.p (other) (23) | |||
| Ertapenem | 0.5–>16 | 8.0 | >16 |
| Imipenem | 0.03–>16 | 4.0 | >16 |
| Amox-clav | 0.12–>32 | 1.0 | 32 |
| Ciprofloxacin | 0.06–>16 | 2.0 | >16 |
| Staphylococcus aureus | |||
| Oxacillin susceptible (375) | |||
| Ertapenem | 0.03–>16 | 0.12 | 0.25 |
| Imipenem | 0.016–>16 | 0.016 | 0.03 |
| Amox-clav | 0.06–8.0 | 1.0 | 1.0 |
| Ciprofloxacin | 0.03–>16 | 0.25 | 0.5 |
| Oxacillin resistant (172) | |||
| Ertapenem | 0.12–>16 | >16 | >16 |
| Imipenem | 0.03–>16 | 16 | >16 |
| Amox-clav | 0.12–>32 | >32 | >32 |
| Ciprofloxacin | 0.12–>16 | >16 | >16 |
| Staphylococcus spp., coagulase negative Oxacillin susceptible (182) | |||
| Ertapenem | 0.03–4.0 | 0.12 | 0.5 |
| Imipenem | ≤0.008–1.0 | 0.016 | 0.06 |
| Amox-clav | ≤0.03–32 | 0.25 | 4.0 |
| Ciprofloxacin | 0.03–2.0 | 0.25 | 0.5 |
| Oxacillin resistant (346) | |||
| Ertapenem | 0.06–>16 | 8.0 | >16 |
| Imipenem | ≤0.008–>16 | 1.0 | >16 |
| Amox-clav | 0.12–>32 | 32 | >32 |
| Ciprofloxacin | 0.06–>16 | 8.0 | >16 |
| Streptococcus agalactiae (206) | |||
| Ertapenem | 0.016–0.25 | 0.06 | 0.06 |
| Imipenem | ≤0.008–0.06 | 0.016 | 0.03 |
| Amox-clav | ≤0.03–0.12 | 0.06 | 0.12 |
| Ciprofloxacin | 0.5–4.0 | 1.0 | 1.0 |
| Streptococcus pneumoniae | |||
| Penicillin susceptible (373) | |||
| Ertapenem | ≤0.008–0.06 | 0.016 | 0.03 |
| Imipenem | ≤0.008–0.03 | ≤0.008 | 0.016 |
| Amox-clav | 0.06–0.25 | 0.06 | 0.06 |
| Ciprofloxacin | 0.5–16 | 1.0 | 2.0 |
| Penicillin intermediate (93) | |||
| Ertapenem | ≤0.008–1.0 | 0.25 | 0.5 |
| Imipenem | ≤0.008–0.5 | 0.12 | 0.25 |
| Amox-clav | ≤0.03–2.0 | 0.5 | 1.0 |
| Ciprofloxacin | 0.5–16 | 1.0 | 2.0 |
| Penicillin resistant (110) | |||
| Ertapenem | 0.12–4.0 | 1.0 | 2.0 |
| Imipenem | 0.12–2.0 | 0.25 | 1.0 |
| Amox-clav | 0.12–8.0 | 1.0 | 8.0 |
| Ciprofloxacin | 0.5–8.0 | 1.0 | 2.0 |
| Streptococcus pyogenes (238) | |||
| Ertapenem | ≤0.008–0.25 | ≤0.008 | 0.016 |
| Imipenem | ≤0.008–0.06 | ≤0.008 | ≤0.008 |
| Amox-clav | ≤0.03–0.12 | ≤0.03 | ≤0.03 |
| Ciprofloxacin | 0.12–2.0 | 0.5 | 1.0 |
| Streptococcus spp.q (other) (77) | |||
| Ertapenem | ≤0.008–4.0 | 0.12 | 0.5 |
| Imipenem | ≤0.008–2.0 | 0.016 | 0.12 |
| Amox-clav | ≤0.03–8.0 | ≤0.03 | 0.25 |
| Ciprofloxacin | 0.016–16 | 0.5 | 8.0 |
| Miscellaneous gram-positive bacteriar (38) | |||
| Ertapenem | ≤0.008–>16 | 0.25 | 2.0 |
| Imipenem | ≤0.008–4.0 | 0.03 | 0.12 |
| Amox-clav | 0.03–>32 | 0.12 | 0.5 |
| Ciprofloxacin | 0.03–>16 | 1.0 | 4.0 |
| Bacteroides fragilis (56) | |||
| Ertapenem | 0.016–4.0 | 0.25 | 1.0 |
| Imipenem | ≤0.008–2.0 | 0.12 | 0.5 |
| Bacteroides spp.s (64) | |||
| Ertapenem | 0.03–8.0 | 0.5 | 2.0 |
| Imipenem | 0.03–4.0 | 0.25 | 1.0 |
| Clostridium perfringens (21) | |||
| Ertapenem | ≤0.008–0.12 | 0.06 | 0.06 |
| Imipenem | 0.03–0.5 | 0.06 | 0.12 |
| Proprionibacterium acnes (21) | |||
| Ertapenem | 0.03–4.0 | 0.06 | 0.25 |
| Imipenem | ≤0.008–1.0 | ≤0.008 | 0.03 |
| Miscellaneous anaerobest (48) | |||
| Ertapenem | ≤0.008–4.0 | 0.12 | 0.5 |
| Imipenem | ≤0.008–2.0 | 0.06 | 0.25 |
Species (no. of isolates): A. anitratus (12), A. baumannii (59), A. haemolyticus (8), and A. lwoffii (7).
Amox-clav, amoxicillin-clavulanate.
Species (no. of isolates): C. amalonaticus (8), C. brackii (1), C. diversus (18), C. farmeri (3), C. freundii (119), C. koseri (66), and Citrobacter spp. NOS (1).
Species (no. of isolates): E. aerogenes (111), E. agglomerans (9), E. asburiae (1), E. cancerogenus (1), E. cloacae (112), E. intermedius (2), E. sakasaki (1), and Enterobacter spp. NOS (2).
Species (no. of isolates): K. ornitholytica (1), K. oxytoca (103), and K. pneumoniae (255).
Species (no. of isolates): M. morganii (94), P. mirabilis (113), P. vulgaris (25), P. rettgeri (18), and P. stuartii (34).
Species (no. of isolates): P. fluorescens/putida group (22), P. paucimobilis (1), P. stutzeri (2), P. vesiculare (1), and Pseudomonas spp. NOS (3).
Species (no. of isolates): S. enterica serovar Tyhi (3) and non-serovar Typhi salmonellae (109).
Species (no. of isolates): S. bovdii (1), S. flexneri (7), S. sonnei (27), and Shigella spp. NOS (2).
Species (no. of isolates): Alcaligenes faecalis (5), Bordetella bronchiseptica (1), Brevundimonas vesicularis (1), Commamonas spp. (1), Flavobacterium breve (1), F. mengosepticum (1), Hafnia alvei (2), Pasteurella spp. NOS (2), Serratia liquefaciens (1), S. rubidaea (1), Shawanella putrefaciens (1), and Yersinia enterocolitica (5).
Species (no. of isolates): H. aegypticus (1), H. aphrophilus (3), H. haemolyticus (4), H. influenzae (233; 86 β-lactamase-positive), H. parahaemolyticus (1), and H. parainfluenzae (30).
Species (no. of isolates): C. afermentans (1), C. amycolatum (1), C. jeikeium (7; resistant to all drugs), C. pseudodiphtheriticum (1), C. striatum (3), C. ureolyticum (3; resistant to all drugs), and Corynebacterium spp. NOS (13).
Includes 10 vancomycin-resistant strains.
Includes 90 vancomycin-resistant strains.
Species (no. of isolates): E. avium (9), E. casseliflavus (3), E. durans (1), E. gallinarum (8), E. raffinosus (1), and Enterococcus spp. NOS (1).
Species (no. of isolates): group C (5), group F (6), group G (21), S. bovis (6), S. milleri (13), S. mitis (2), S. mutans (2), S. salivarius (3), S. sanguis (4), and S. viridans NOS (15).
Species (no. of isolates): Aerococcus spp. NOS (2), A. urinae (4), Bacillus spp. NOS (8), Lactobacillus spp. NOS (10), Micrococcus spp. NOS (13), and L. monocytogenes (1).
Species (no. of isolates): B. fragilis group, NOS (9), B. ovatus (9), B. thetaiotaomicron (19), B. uniformis (11), B. vulgatus (5), and Bacteroides spp. NOS (11).