Optimization of P3 residue of new candidates for the SARS-CoV-2 M^pro α-ketoamide inhibitors^a.

Compound	Formula: P3–P2–P1–P1′	ΔΔEint,MMa [kcal mol−1]	M w b [g mol−1]
C9		0.7	589.7
C11		1.1	605.7
C12		0.0	617.7
C13		−0.9	633.7
C14		−2.8	649.7
C15		−0.5	646.7
C16		−0.7	634.7
C17		−3.6	650.7

^{a a,b}See the footnote of Table 1.