Cooperativity between P3, P2, P1 and P1′ residues and downsizing of optimized SARS-CoV-2 M^pro α-ketoamide and ester inhibitor candidates^a.

Compound	Formula: P3–P2–P1–P1′	ΔΔEint,MMa [kcal mol−1]	M w b [g mol−1]
C25		−14.5	692.7
C29		−14.4	626.7
C30		−11.2	560.6
C31		−16.3	638.7
C32		−15.8	704.7
C33		−16.7	652.7
C34		−16.8	640.7

^{a a,b}See the footnote of Table 1.