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. 2022 May 2;132(9):e152864. doi: 10.1172/JCI152864

Figure 6. Tim-3 and PD-1 blockades impede the trogocytosis of CD8+ TILs in vivo.

Figure 6

(A and B) Representative dot plots (left) and summary data (middle and right) showing frequencies of PD-1+Tim-3+ and PS+PD-1+Tim-3+ CD8+ TILs (day 21) in mice implanted with YUMMER 1.7 (A) or B16-OVA (B) and treated with indicated mAbs. (C) Representative dot plots (left) and summary data (n = 5–8, right) showing frequencies of CD11c+, CD209+, and PD-L1+ PD-1+Tim-3– and PD-1+Tim-3+ CD8+ TILs (day 21) in mice implanted with YUMMER 1.7 and treated with indicated mAbs. Results shown are from 1 experiment, representative of 3 independent experiments (IgG, n = 8; aTim-3, n = 8; aPD-1, n = 6; aPD-1 + aTim-3, n = 5). P values were obtained by 1-way ANOVA followed by Tukey’s multiple-comparison test (A–C) or Kruskal-Wallis test followed by Dunn’s multiple-comparison test (C). **P < 0.01; ***P < 0.001; ****P < 0.0001. Data indicate mean ± SD.