Figure 7. Myeloid-derived Vegfc ameliorates scarring and infarct size after MI.

Mice of the indicated genotypes were subjected to experimental MI after ligation of the LAD artery. (A) The AAR was determined by intramyocardial circulation of fluorescent microbeads, and the infarct (INF) size was determined by TTC staining 7 days after the MI. (B) Quantification of the AAR and infarct size. n = 4 per group. **P < 0.0018, by 2-tailed, unpaired t test. (C) Representative Picrosirius red staining and quantification of fibrosis in cardiac sections on day 28 after the ligation procedure. n = 6 per group. *P < 0.05, by 2-tailed, unpaired t test.