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. 2022 Apr 8;7(7):e156559. doi: 10.1172/jci.insight.156559

Figure 3. Cytokine profiles of vaccine-induced SARS-CoV-2–specific T cells.

Figure 3

(A) Bar plots show the expression of TNF-α, IL-2, and IFN-γ in CD4+ T cells and CD8+ T cells. Error bars represent mean ± SEM (*P < 0.05, ****P < 0.0001, Wilcoxon paired t test, n = 21). (B) Dot plots summarize the expression of TNF-α, IL-2, and IFN-γ of SARS-CoV-2–specific CD4+ and CD8+ T cells from 21 vaccinated individuals. (C) The UMAP plots (left) show cytokine hierarchies of SARS-CoV-2–specific CD4+ (top) and CD8+ T cells (bottom). The bar plots (right) show the frequencies of SARS-CoV-2–specific CD4+ (top) and CD8+ (bottom) T cells secreting 1 (red), 2 (blue), and 3 (green) cytokines from 21 vaccinated individuals. (D) The UMAP plots show TNF-α, IL-2, and IFN-γ expression patterns of SARS-CoV-2–specific CD4+ (top) and CD8+ T cells (bottom). Color bars indicate the scaled expression levels. (E) The bubble plot shows the expression levels of 22 cytokines from 4 donors (2 high responders and 2 low responders). (F) Bar plot shows the T cell and monocyte cytokine scores from 4 donors. IP-10, IFN-γ–induced protein 10; MCP-1, monocyte chemoattractant protein-1; MIP-1a, macrophage inflammatory protein, UMAP, uniform manifold approximation and projection.