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. 2022 Apr 8;7(7):e152330. doi: 10.1172/jci.insight.152330

Figure 4. Inhibition of Piezo1 prevents folic acid–induced kidney fibrosis.

Figure 4

(A and B) Representative immunoblots and corresponding densitometry analysis of Piezo1, fibronectin, and collagen I protein abundance in the kidney of CTL, FAN, and FAN+GsMTx4 mice. Data are shown as mean ± SEM (n = 5 in CTL group, n = 6 in FAN and FAN+GsMTx4 group). (C) Photomicrographs of Masson’s staining in the kidney of CTL, FAN, and FAN+GsMTx4 mice (original magnification, 400×). (D) mRNA levels of TGF-β1, α-SMA, and fibronectin in the kidney of CTL, FAN, and FAN+GsMTx4 mice. Data are shown as mean ± SEM (n = 5 in CTL group, n = 6 in FAN and FAN+GsMTx4 group). *P < 0.05 when compared with CTL mice and #P < 0.05 when compared with FAN mice by 1-way ANOVA with Student-Newman-Keuls test. CTL, control; FAN, folic acid nephropathy.