Skip to main content
. 2022 May 2;132(9):e153436. doi: 10.1172/JCI153436

Figure 5. Human GC lymphomas are characterized by activation of the SSP pathway.

Figure 5

(A and B) Representative immunohistochemical staining (×20 magnification) and quantification for PHGDH and PSAT1 abundance in sections of human diagnostic biopsies from patients with Burkitt lymphoma (BL), Diffuse Large B cell lymphoma (DLBCL), and Chronic lymphocytic leukemia (CLL). The statistical difference was analyzed using the ordinary 1-way ANOVA. (C and D) IHC analysis (×40 magnification) for PHGDH and PSAT1 in proliferation centers (PC) and resting zone (RZ) areas in sections from biopsies collected from patients with chronic lymphocytic leukemia (CLL), and quantification. Individual samples (dots) and means (bars) values are plotted. The statistical difference was analyzed using the Mann-Whitney U test. (E) Kaplan-Meier survival analysis of patients with DLBCL from a published data set (GSE10846) (44). Patients whose PHGDH/PSAT1 mRNA levels were within the top quartile were grouped as PHGDH/PSAT1 high; those with PHGDH/PSAT1 mRNA levels within the bottom quartile were grouped as PHGDH/PSAT1 low. Data are shown as the mean ± SEM. ****P < 0.0001, by 1-way ANOVA (B) or by Mann-Whitney U test (D). Survival analysis were conducted with log-rank (Mantel-Cox) test (E).