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. 2022 Apr 8;7(7):e156424. doi: 10.1172/jci.insight.156424

Figure 6. The long-term effects of SG on male offspring are reversed by maternal treatment with Exendin 9-39.

Figure 6

(A and B) Weight and nonfasting glucose levels of male offspring of sham- or SG-operated mice treated or untreated with Exendin 9-39 during pregnancy. The dashed black line denotes a switch from normal chow to a high-fat high-sucrose diet. (C–F) Oral glucose tolerance test, AUC, fasting glucose, and insulin levels at week 15 of the 4 experimental groups. (G) Representative H&E staining of the liver of the 4 experimental groups. (H) Histological grade of hepatic steatosis in the 4 experimental groups. Blue: male offspring of sham-operated mice untreated with Exendin 9-39 during pregnancy (full) or treated with Exendin 9-39 (dashed); Red: male offspring of sham-operated mice untreated with Exendin 9-39 during pregnancy (full) or treated with Exendin 9-39 (dashed). *P < 0.05, **P < 0.01 by 2-way ANOVA with Tukey HSD post hoc test in D, F, H, and I or by 3-way continuous measures ANOVA in A–C and E. All panels sham Ex9– n = 7, sham Ex9+ n = 7, SG Ex9– n = 7, SG Ex9+ n = 6. *P < 0.05, **P < 0.01 for the comparison between sham-Ex9– and SG-Ex9-. †P < 0.05, ††P < 0.01 for the comparison between SG-Ex9– and SG-Ex9+. ‡P < 0.05, ‡‡P < 0.01 for the comparison between sham-Ex9– and sham-Ex9+.