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. 2022 Apr 8;7(7):e153488. doi: 10.1172/jci.insight.153488

Figure 11. Model for a role of epithelial KLF5 in guarding against intestinal inflammation.

Figure 11

Left shows the homeostatic state of the colon in which KLF5 regulates proliferation of crypt epithelial cells (27). Nuclear-cytoplasmic shuttling of KLF5 has previously been demonstrated (56). Middle panel shows colitis with intact KLF5, which promotes IL-22–mediated epithelial regeneration by assisting in the nuclear localization of p-STAT3. Right panel shows colitis in the absence of KLF5 due to the lack of p-STAT3 nuclear localization in response to IL-22.