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. 2022 Apr 8;7(7):e153488. doi: 10.1172/jci.insight.153488

Figure 5. Th17 effector cytokines are essential for the pathogenesis of colitis when Klf5 is deleted.

Figure 5

(A) Weight change after 5 days of neutralizing antibody and CO or TAM treatment of Klf5ΔIND mice (n = 4). (B) Clinical scores. Max for the clinical score is 12 and quantified with 3 categories: stool consistency, weight loss, and fecal blood (n = 4). (C) H&E staining of Klf5ΔIND mice treated with IgG1 or αIL-17A neutralizing antibody and CO or TAM (n = 4). (D) Histological scores. Max for the histological score is 11 and quantified with 3 categories: crypt damage, inflammatory cells in lamina propria, and ulcers (n = 4). Data from graphs represent mean ± SEM. **P < 0.01; ***P < 0.001; 1-way ANOVA. Scale bar: 70 μm.