Fig. 3. Three-dimensional representation main protease–rutin (up, left), papain-like protease–velpatasvir (up, right), and spike protein–lomitapide (down). Each protein is represented with ribbons (pink, green and cyan respectively) and ligands are in ball-and-stick. Hydrogen bonds are depicted as yellow dotted lines and π–π stacking as cyan dotted lines. Interacting residues are labelled in yellow.