Summary of potential metabolites and their associated metabolic pathways detected by ¹H NMR and LC-ESI-MS/MS of urine from tetracycline treated rats.

Pathways	Metabolite	Detection
TCA cycle	Citrate	NMR
Phenylalanine metabolism	Hippurate	NMR
Gut metabolism	Xanthurenic acid	LC-MS/MS
Lysine degradation	Lysine	NMR
Taurine and hypotaurine metabolism	Taurine	NMR
Purine metabolism	Inosine	LC-MS/MS
Arginine and proline metabolism
Arginine and proline metabolism	Proline	LC-MS/MS