Table 2.

Univariable and multivariable analyses of PFS

Variable	Univariable analysis		Multivariable analysis
	HR (95% CI)	P	HR (95% CI)	P
International staging system
I	1.00		1.00
II	1.00 (0.20–4.95)	0.998	1.58 (0.25–9.95)	0.627
III	2.14 (0.58–7.91)	0.254	3.21 (0.63–16.26)	0.159
Cytogenetics
Standard risk	1.00		1.00
High-risk	1.89 (0.66–5.46)	0.237	1.49 (0.47–4.69)	0.497
ASCT
No	1.00		1.00
Yes	0.46 (0.16–1.29)	0.139	0.54 (0.17–1.71)	0.293
Response status
sCR	1.00		1.00
CR	1.64 (0.32–8.50)	0.553	1.80 (0.33–9.95)	0.500
VGPR	7.98 (2.58–24.71)	< 0.001	4.96 (1.47–16.72)	0.010
MRD
Negative	1.00		1.00
Positive	4.04	0.011	3.23 (1.01–10.34)	0.048

Abbreviations: PFS, progression-free survival; HR, hazard ratio; CI, confidence interval; ASCT, autologous stem cell transplantation; sCR, stringent complete remission; CR, complete remission; VGPR, very good partial response; MRD, minimal residual disease.