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Neutrophils and platelets participate in an activation loop. Activated neutrophils release S100A8/A9, which then signals through RAGE on Kupffer cells in the liver for increased TPO production. TPO interacts with its receptors on megakaryocytes to upregulate platelet production. These platelets can be activated by NETs, and in turn, the platelets activate neutrophils, perpetuating the cycle. TPO, thrombopoietin. Color images are available online.
