FIG. 1.

GBM6 cell expansion in response to matrix-bound HA and extracellular hypoxia. (A) Overall GBM6 cell number not affected by hypoxia, but increases significantly with the presence of matrix-immobilized HA. (B) GBM6 cell metabolic activity showed an early increase in response to hypoxia, but over extended cultures is significantly increased in response to matrix-immobilized hypoxia regardless of hypoxia versus normoxia. Sample numbers were all n = 3. ^p < 0.05 for +/− hypoxia; *p < 0.05 for +/− HAMA. GBM, glioblastoma; HA, hyaluronic acid; HAMA, methacrylamide-functionalized hyaluronic acid. Color images are available online.