Quinazoline-based drugs in clinical trials.
| Name | Status | Structure | Indication |
|---|---|---|---|
| Afatinib dimaleate | Phase II |
|
Targeted treatment in cancers with HER2 genetic changes134 |
| RXDX-105 | Phase I/Ib |
|
Non-small cell lung cancer (NSCLC)135 |
| Icotinib | Phase II |
|
Neurofibromatosis type 2 (NF2)136 |
| Dacomitinib | Phase II |
|
Advanced non-small cell lung cancer137 |
| Doxazosin mesylate | Phase II |
|
Nightmares, sleep disturbance, and non-nightmare clinical symptoms in PTSD138 |
| Letermovir (MK-8228) | Phase II |
|
Prevention of cytomegalovirus reactivation in patients with haematological malignancies treated with alemtuzumab139 |