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IFN-γ producing CD4+ and CD8+T cells against S peptides pre-vaccination (BL), and after the first (1D) and second dose (2D) of BNT162b2 vaccine, according to pre-existing immunity (green bars) or not (blue bars) in healthcare workers (HCWs). Each dot represents an individual prevaccination or after the first and second dose of vaccine. Boxes represent median and interquartile range.
