Summary of stress degradation of simeprevira.
| Degradation study | Exposure conditions | Time | DPs formed & Rt (min) | % Degradation |
|---|---|---|---|---|
| Acidic degradation | 0.5 M HCl at 100 °C | 5 hours | DP 1 (Rt = 2.890) | 26.63 |
| DP 2 (Rt = 5.455) | ||||
| DP 3 (Rt = 6.987) | ||||
| Alkaline degradation | 1 M NaOH at 100 °C | 5 hours | No DPs formed | No degradation |
| Oxidative degradation | 3% w/v H2O2 at 100 °C | 5 hours | DP 4 (Rt = 1.449) | 21.87 |
| DP 5 (Rt = 2.622) | ||||
| Thermal degradation | Oven at 100 °C | 10 hours | No DPs formed | No degradation |
a
DPs: degradation products, Rt: retention time.