Design of experiment (DOE) for simeprevir robustness testing.

Exp. no.	pH	Methanol	Wavelength	Flow rate
1	4.2	88	235	1.2
2	4.2	92	235	0.8
3	4.2	92	239	0.8
4	3.8	92	239	1.2
5	4.2	88	239	1.2
6	3.8	92	235	1.2
7	3.8	88	239	0.8
8	3.8	88	235	0.8
9	4	90	237	1
10	4	90	237	1
11	4	90	237	1