Comprehensive list of solvents that have been used in relation to GSPPS, including key references. Solvent classification has been carried out by inspection of REACH authorisation, candidate list (SVHC, Substances of Very High Concern),¹⁴ PACT (the Public Activities Coordination Tool),³² endocrine disruptors and CMR (Carcinogenic, Mutagenic or toxic for Reproduction). Solvents are labelled as unaffected by REACH (green) or affected by REACH (red). It should be noted that many solvents that currently are not affected by REACH are under investigation due to environmental concerns and may become affected in the future. Major REACH concerns are summarised in a separate column. Supply is listed in five categories based on the amount of solvent manufactured and/or imported to the EEA annually as reported in ECHA³³.

^a1 black circle indicates an annual supply in the EEA of <100 tonnes, 2 circles = 100–1000 tonnes, 3 circles = 1000–10 000 tonnes, 4 circles = 10 000–100 000 tonnes, and 5 black circles indicates >100 000 tonnes; n.d. = no data available; conf. = confidential; n/a = not applicable for standard solvents.

^bImidazolium-based ionic liquids are associated with concerns regarding their ecotoxicity and thermal decomposition.^45,46

^cPer- and polyfluoroalkyl substances are currently under investigation by ECHA REACH because these substances are considered to be persistent. The use of per- and polyfluoroalkyl substances will likely be restricted in the future.