Fmoc-removal with alternative bases to piperidine reported by Lebl and co-workers65.
Base (25% in DMF) | t 1/2 a (min) |
---|---|
Piperidine | 2.0 |
2-Me-piperidine | 3.0 |
3-Me-piperidine | 1.9 |
4-Me-piperidine | 2.0 |
4-Me-piperazine | 7.8 |
Fmoc-Ile CTC-resin was placed in a glass cuvette and the deprotection mixture was added. The UV absorbance at 301 nm was determined every 2 min.